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Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Humans Escherichia coli Benzamides Quinolines Nitriles Aniline Compounds Piperazines Pyrimidines Thiazoles Recombinant Proteins
2016/5/25
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are currently used to treat CML, but resistance to t...
Expression and Function of the PRL Family of Protein Tyrosine Phosphatase
PRL phosphatase PTP4A DSP cancer
2015/5/22
The PRL family of enzymes constitutes a unique class of protein tyrosine phosphatase, consisting of three highly homologous members (PRL-1, PRL-2, and PRL-3). Family member PRL-3 is highly expressed i...
Effects of Ca2+ and HCO3- on Capacitation, Hyperactivation and Protein Tyrosine Phosphorylation in Guinea Pig Spermatozoa
Capacitation Hyperactivation Tyrosine Phosphorylation Sperm
2016/4/29
In our previous report, we demonstrated that the tyrosine phosphorylation of sperm proteins (TPSP) of guinea pig was associated with capacitation and hyperactivation (CAHA), and Ca2+ and HCO3- were re...
Capacitation-associated Changes in Protein-tyrosine-phosphorylation, Hyperactivation and Acrosome Reaction in Guinea Pig Sperm
Acrosome Reaction Capacitation Hyperactivation Tyrosine Phosphorylation Semen
2016/4/27
The aim of this study was to evaluate the effects of Ca2+, HCO3- and BSA on the in vitro capacitation-associated protein tyrosine phosphorylation, hyperactivation and acrosome reaction in guinea pig s...
Activation of Src tyrosine kinase in microglia in the rat hippocampus following transient forebrain ischemia
Src Phosphorylation Transient forebrain ischemia Microglia
2014/3/31
o better understand the pathophysiological role of Src protein, a non-receptor protein tyrosine kinase of 60 kDa, in the ischemic brain,
we investigated the time course and regional distribution of a...