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Ischemic preconditioning (IPC, which was originally identified by Murry et al.) provides powerful protection to the ischemic myocardium. Although a variety of intracellular signaling pathways have bee...
Identified both NADPA diaphorase activity and nNOSimmunoreactivity in mitochondria from neuronal structures ofwild-type, but not in nNOS knockout mice.Failed to show any positive evidence for the pres...
Post-ischaemic reperfusion may precipitate cardiomyocyte death upon correction of intra-cellular acidosis due in part to mitochondrial permeability transition. We investigated whether glycine, an ami...
In 1976, Hunter and Haworth first characterized the mitochondrial permeability transition in beef heart mitochondria. In 1987, Martin Crompton et al. implied that the pore is a unique molecular entit...
It is well known that mitochondrion is the power source of cells and its function is dependent on the activities of respiratory chain complexes. In cardiac myocytes mitochondria are abundant constitut...
Mitochondrial nitric oxide synthase (mtNOS) is a fine regulator of oxygen uptake and reactive oxygen species that eventually modulates the activity of regulatory proteins and cell cycle progression....
In protocol 1, New Zealand White rabbits underwent either no intervention (sham group) or 10 min of ischemia followed by 5 min of reperfusion, preceded (PC) or not (C; control) by one episode of 5 mi...

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