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RNA Synthesis in the Tracheal Epithelial Cells of Aging Mice as Revealed by Electron Microscopic Radioautography
RNA synthesis Macromolecular Microscopic radioautography 3H-uridine
2015/7/21
For the purpose of studying the aging changes of macromolecular synthesis in the tracheal epithelial cells of experimental animals, we studied 10 groups of aging mice during development and aging from...
Solid-Phase Synthesis of N-Carboxyalkyl Unnatural Amino Acids
solid-phase synthesis amino acids combinatorial chemistry
2015/5/21
A novel route has been developed for the solid-phase synthesis of N-carboxyalkyl unnatural amino acids as potential metalloprotease inhibitors. The key step involves a nitrogen alkylation of resin-bou...
Synthesis and antifungal activity of some new 1,2,4-Triazolo [3,4-b] [1,3,4] Thiadiazines
1,2,4-Triazolo [3,4-b] [1,3,4] thiadiazine Heterocycles Fungicides
2010/1/6
A new series of 5-aryl - 3 - (2 - furyl) - (7H) - s - triazolo [3, 4 - b] [1 , 3 , 4 ] thiadiazines were prepared by the reaction of 4-amino - 5 - ( 2 - furyl) - 2 , 4 - dihydro - 3H - 1 , 2 , 4 - tri...
Synthesis and Calcium channel antagonist activity of Nifedipine analogues with Chloroindolyl substituent
Synthesis Calcium channel antagonist activity Nifedipine analogues Chloroindolyl substituent
2010/1/6
Various diester analogues of nifedipine in which the ortho nitrophenyl group at position 4 were replaced by 3-chloro-1H-2-indolyl substituent, were synthesized and evaluated as calcium antagonists on ...
Synthesis and antimycobacterial activity of 2-hydroxyacetamides
2-Hydroxyacetamides Glycolic acid acetonide Alamar blue Assay Hydrophilicity
2009/12/30
On the basis of the structural similarity of 2-hydroxyacetamides (glycolamides) with N-glycolylmuramic acid residues of the cell wall of Mycobacterium tuberculosis several of these compounds were prep...
Synthesis and smooth muscle Calcium channel antagonist effect of Alkyl, Aminoalkyl 1,4-Dihydro-2,6-Dimethyl-4-Nitroimidazole-3,5 Pyridine Dicarboxylates
Ca+² channel antagonist DHP Arylpiperazine
2009/12/29
The discovery that 1,4-dihydropyridine (DHP) class of calcium channel antagonist inhibits the Ca+² influx represented a major therapeutic advance in the treatment of cardiovascular diseases such ...
The Role of Pr otein Synthesis in the Adhesion of Chinese Hamster Lung Cells
Lung Cells Adhesion Synthesis
2009/6/30
In order to determine the effect of endogenous protein synthesis on CHL cell adhesion, the initial attachment of these cells to tissue culture dishes was measur ed in the pr esence of 1µgml -1 e...
The synthesis of a panel of human monoclonal antibodies with neutralizing activities against viral infectious diseases
phage display combinatorial biology therapeutic molecule
2010/12/10
The synthesis of a panel of human monoclonal antibodies with neutralizing activities against viral infectious diseases.
Synthesis, development and preclinical comparison of two new peptide based freeze-dried kit formulation 99mTc-EDDA-Tricine-HYNIC-TOC and 99mTc-EDDA-Tricine-HYNIC-TATE for somatostatin receptor positive tumor scintigraphy
99mTc Somatostatin Tyr3-octreotide Tyr3-Octreotate HYNIC Kit formulation
2010/4/7
Somatostatin receptor (sstr) scintigraphy with [111In diethylenetriaminepentaacetic acid]-octreotide ([111In-DTPA]-OC) has became a routine diagnostic procedure in oncology. However, it suffers from s...
SYNTHESIS AND PHARMACOLOGICAL EFFECTS OF BUTADIENE AND CYCLOPENTADIENE ADDUCTS OF METHANDROSTENOLONE IN RATS
Methandrostenolone 1,3 butadiene Cyclopentadiene Diels-Alder adducts Anti-androgen
2010/2/5
In this study the reactivity of methandrostenolone or [(17b)-17-hydroxy-17-methylandrosta-1, 4-diene-3-one], as a dienophil in a Diels-Alder type cycloaddition reaction was investigated. The purpose o...
Molecular regulation of human IgE synthesis
atopy CD40 ligand IgE interleukin-4 switch recombination
2010/11/29
Human IgE synthesis is largely dependent on the production of interleukin (IL)-4 or IL-13 and the expression of CD40 ligand. Such B cell help is not only provided by CD4+ T cells, but also by CD8+ T c...
Mechanical strain-induced DNA synthesis and cell proliferation in human airway smooth muscle cells through extracellular signal-regulated kinase
airway smooth muscle cell extracellular signal-regulated kinase mechanical strain
2010/11/25
An increased airway muscle content is one of the characteristic features of airway remodeling. Proinflammatory substances, growth factors and mechanical strain promote airway muscle cell proliferation...
Blocking the CD154-CD40 interaction with anti-CD154 antibody differentially regulates interleukin-4 synthesis in T cells and IgE production in B cells
CD154 CD40 germline Cε IgE interleukin-4
2010/11/25
Using severe combined immunodeficiency mice engrafted with peripheral blood mononuclear cells from atopic patients, we analyzed the regulatory effects of anti-CD154 antibody on the in vivo induction o...
Recombinant soluble form of the high-affinity IgE receptor α subunit and anti-IgE antibody inhibit IgE synthesis by IgE-expressing B cells through distinct pathways
apoptosis divalent recognition IgE-binding agents IgE-expressing B cells interleukin-6 monovalent recognition
2010/11/24
Background: Both a recombinant soluble form of the high-affinity IgE receptor α subunit (rsFcεRIα) and anti-IgE antibody have been shown to be involved in the regulation of IgE synthesis. However, the...