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A serendipitous finding lends new insight into how atopic dermatitis develops（图）
特应性皮炎 皮肤病 皮肤
2023/7/12
Atopic dermatitis, a common skin condition affecting both children and adults, is often thought of as an inflammatory disease that arises from a breakdown in the barrier function of the skin. Now a ne...
Urinary Eosinophil-derived Neurotoxin Concentrations in Patients with Atopic Dermatitis: A Useful Clinical Marker for Disease Activity
atopic dermatitis eosinophil eosinophil-derived neurotoxin visual analogue scale
2010/11/18
Background: It has been reported that measurements of eosinophil-derived neurotoxin (EDN) may be useful for identifying eosinophil activities in allergic diseases including atopic dermatitis.
Methods...
An Improved Mouse Model of Atopic Dermatitis and Suppression of Skin Lesions by an Inhibitor of Tec Family Kinases
allergen atopic dermatitis mite Tec Th2
2010/11/18
We established a highly efficient, highly reproducible protocol to induce skin lesions in NC/Nga mice and successfully applied it to show the efficacy of terreic acid in treating skin lesions. This mo...
Suplatast/Tacrolimus Combination Therapy for Refractory Facial Erythema in Adult Patients with Atopic Dermatitis—A Meta-Analysis Study—
atopic dermatitis erythema meta-analysis suplatast tacrolimus
2010/11/18
Background: Combination of suplatast tosilate with tacrolimus ointment was reported to reduce the dose of tacrolimus ointment with maintained treatment efficacy for refractory facial erythema in atopi...
Detection of anti-IgE and anti-FcεRI α chain auto-antibodies in patients with atopic dermatitis
atopic dermatitis auto-antibody high affinity IgE receptor immunoglobulin E
2010/11/25
Anti-IgE and anti-FcεRI α chain auto-antibodies have been detected in the sera of atopic and non-atopic subjects; however, the biological activity of these auto-antibodies is still unclear. These two ...
Eosinophil hypersegmentation is a possible marker to monitor the disease activity of atopic dermatitis
atopic dermatitis eosinophils nuclear lobes of eosinophils
2010/11/25
Background: In the present study, we tried to clarify whether nuclear hypersegmentation of peripheral blood eosinophils is correlated with peripheral eosinophil counts and/or the activity of atopic de...
Evaluation of patch testing in atopic dermatitis using commercially available environmental antigens
atopic dermatitis late phase reaction patch testing
2010/11/25
The patch test positivity rate increased in proportion with the duration of antigen application, with a maximum of 15.6% for mite antigen and a minimum of 4.7% for cedar antigen by 72 h. There were no...
Interleukin-18 is associated with the severity of atopic dermatitis
atopic dermatitis bronchial asthma IgE interferon-γ interleukin-18 interleukin-18 promoter
2010/11/24
The plasma IL-18 level was elevated, particularly in patients with atopic dermatitis. As the clinical severity of atopic dermatitis increased, the plasma IL-18 level also tended to increase. These fin...
Transient shift toward T helper 1 cytokine production by peripheral blood mononuclear cells following successful treatment of patients with atopic dermatitis
atopic dermatitis cytokines interferon-γ interleukin-10 interleukin-12 peripheral blood mono-nuclear cells response to treatment
2010/11/24
Interferon-γ and interleukin (IL)-12 pro-duction increased significantly after 2 weeks treatment (P < 0.005 and P < 0.05, respectively), while IL-10 production decreased significantly after 2 and 4 we...
Effects of neuropeptides in the development of the atopic dermatitis of mouse models
atopic dermatitis calcitonin gene-related peptide neuropeptides olopatadine hydrochloride substance P
2010/11/22
It is suggested that repeated contact allergic dermatitis or mental stress may promote the development and exacerbation of AD and that substance P has a role in this response. In addition, it seems th...
Newly Developed Phototherapy for Atopic Dermatitis
atopic dermatitis narrow-band UVB therapy phototherapy psoralens plus ultraviolet A (PUVA) therapy ultraviolet A-1 (UVA1) therapy
2010/11/19
In the treatment of atopic dermatitis ultraviolet therapy is considered the second line of treatment, when adverse reactions occur and control is difficult with topical steroid treatment given as firs...
Therapeutic Guidelines for Atopic Dermatitis 2002
anti-histamine atopic dermatitis steroid tacrolimus therapeutic guidelines
2010/11/19
We summarized the Therapeutic Guidelines for Atopic Dermatitis 2002, and outlined important points with reference to medical care and management of atopic dermatitis.
Seasonal variation in the month of first visit for atopic dermatitis patients
atopic dermatitis bias birth periodicity risk factor season
2010/11/29
The total number of new attendant patients diagnosed as having atopic dermatitis at our dermatology out-patient clinic during the 7 year period from 1989 to 1995 was 10 156. Patients from each year du...
Development of antigen-specific IgE antibodies in atopic and non-atopic infants: Diagnostic value of low levels of IgE against egg white in infants with atopic dermatitis
atopic dermatitis egg infant milk RAST
2010/11/29
To analyze the development of antigen-specific IgE in infants and its clinical usefulness, the levels of IgE antibodies against egg white (f1) and cows' milk (f2) in 33 sera from cord blood, 118 sera ...