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ELUCIDATING MECHANISMS THAT LEAD TO PERSISTENT ANXIETY-LIKE BEHAVIOR IN RATS FOLLOWING REPEATED ACTIVATION OF CORTICOTROPIN-RELEASING FACTOR RECEPTORS IN THE BASOLATERAL AMYGDALA
anxiety corticotropin-releasing factor somatostatin amygdala basolateral amygdala
2015/5/21
Anxiety disorders are estimated to impact 1 in 4 individuals within their lifetime. For some individuals, repeated episodes of the stress response leads to pathological anxiety and depression. The str...
Elevated Mechanical Loading When Young Provides Lifelong Benefits to Cortical Bone Properties in Female Rats Independent of a Surgically Induced Menopause
d mechanical loading exercise menopause bone properties
2014/11/6
Exercise that mechanically loads the skeleton is advocated when young to enhance lifelong bone health. Whether the skeletal benefits of elevated loading when young persist into adulthood and after men...
Nanoscale Changes in Collagen are Reflected in Physical and Mechanical Properties of Bone at the Microscale in Diabetic Rats
Zucker diabetic Sprague-Dawley Atomic Force Microscopy Raman Spectroscopy Reference Point Indentation D-spacing Advanced Glycation End Products
2014/11/6
Diabetes detrimentally affects the musculoskeletal system by stiffening the collagen matrix due to increased advanced glycation end products (AGEs). In this study, tibiae and tendon from Zucker diabet...
Liver Function and Structure in Rats Treated Simultaneously with Cadmium and Mercury
Cadmium Mercury Liver Toxicity Rat
2013/1/31
The effect of cadmium chloride (150 mg/l) and mercury (II) chloride (80 mg/l) either alone or in combination in drinking water for 4 weeks on function and structure of the liver of male rats was studi...
Aphrodisiac Activity of Aqueous Extract of Phoenix dactylifera Pollen in Male Rats
Aphrodisiac Activity Microdialysis Dopamine Testostrone
2013/1/29
Aim of study: Ancient literature alluded to the use of a number of plants/preparations as sex enhancer. One of such botanicals is Phoenix dactylifera in which the pollen grain has been acclaimed to be...
Evaluation of Biochemical, Hematological and Histological Parameters in Non Diabetic and Diabetic Wistar Rats Fed with Monosodium Glutamate
MSG Glutamate Wistar Rat Diabetes
2013/1/29
The parenteral or oral administration of monosodium glutamate (MSG) has been reported to have a deleterious effect on the hypothalamic arcuate nucleus, which changes appetite control. This alteration ...
Pinealectomy and Exogenous Melatonin Regulate Anxiety-Like and Depressive-Like Behaviors in Male and Female Wistar Rats
Pinealectomy Melatonin Sex Dependent Anxiety Depression Behavioral Tests
2013/1/30
The main objective of this work was to 1) study the influence of endogenous melatonin (Mel) abolishment via pinealectomy and 2) explore exogenous Mel effect on anxiety-like and depressive-like behavio...
Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia
Alzheimer Amyloid Beta Lavandula angustifolia
2013/1/30
An important marker in neurodegenerative Alzheimer’s disease (AD) is abnormal production of amyloid beta (Aβ) peptide leading to formation of plaques in the brain. Through decreasing Aβ aggregates, an...
Effects of the Supercritical Fluid Extraction of Dahurian Angelica Root and Szechwan Lovage Rhizome on Spontaneous Hypertension Rats
Dahurian Angelica Root Szechwan Lovage Rhizome LVH Myocardial Fibrosis SHR
2013/1/29
The supercritical fluid extraction of Dahurian Angelica Root (Bai Zhi) and Szechwan Lovage Rhizome (Chuan Xiong) was named as BCC. In the study, we investigated whether BCC had effects on left ventric...
Silica inflammation modulates lipoperoxide and thi-obarbituric acid reactive substances levels in liver and glucose concentration in blood of alloxan diabetic rats
Silica Granulomatous Inflammation Alloxan Diabetic Rats Liver Lipid Peroxidation Blood Glucose
2013/1/30
Inflammatory granulomatous diseases are cha- racterized by a high concentration of granu- lomas in tissue interstitium in which phagocytic cells that produce active oxygen and nitrogen metabolites are...
Enrichment Discrimination Behavior in Spontaneously Hypertensive Rats
Attention Deficit Enrichment Discrimination Spontaneously Hypertensive Rat Atomoxetine
2013/1/29
Objectives: 1) To reveal, among spontaneously hypertensive rats, subpopulations that diverge in attention to objects enriching an empty cross-maze; 2) To evaluate effect of clinically efficient drug f...
5-HT2A Receptor Activation Normalizes Exaggerated Fear Behavior in p-Chlorophenylalanine (PCPA)-Treated Rats
Fear Conditioning Startle Reflex 5-HT2 DOI Ketanserin SB 206553
2013/1/29
Deficits in serotonin (5-hydroxytryptamine, 5-HT) neurotransmission are implicated in abnormal emotional behaviors such as aggression, anxiety, and depression. However, the specific 5-HT receptor mech...
Vitamin C modulates oxidative stress-induced colitis in rats
Vitamin C colitis histopathology oxidative stress rats
2010/11/22
Free radicals are an important factor in the etiopathogenesis of colitis and may increase oxidative damage. The antioxidant vitamin C efficiently scavenges free oxygen radicals. The present study aime...
Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats
Electrolyzed-reduced ethanol-induced
2009/12/16
Ethanol consumption disturbs the balance between the pro- and anti-oxidant systems of the organism, leading to oxidative stress. Electrolyzed-reduced water (ERW) is widely used by people in East Asia ...
Administration of anti-glucagon-like peptide-2 serum suppresses epithelial cell proliferation of the distal small intestine in weanling rats
weanling rats cell proliferation
2009/12/16
We investigated the effects of endogenous glucagon-like peptide-2 (GLP-2) on the development of intestinal mucosa in weanling rats. Three-week-old male weanling Sprague-Dawley rats were administered e...