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Theaflavin-regulated Imd condensates control Drosophila intestinal homeostasis and aging
红茶 抗衰老 茶黄素
2023/4/19
Black tea is the most widely consumed tea drink in the world and has consistently been reported to possess anti-aging benefits. However, whether theaflavins, one type of the characteristic phytochemic...
2017冷泉港学术会议：果蝇神经生物学（Cold Spring Harbor conference on Neurobiology of Drosophila）
2017 冷泉港 学术会议 果蝇神经生物学
2017/2/14
We are pleased to announce the seventeenth biennial Neurobiology of Drosophila meeting, which will be held at Cold Spring Harbor Laboratory. The meeting will begin at 7:30 pm on the evening of Tuesday...
The role of notch signaling in regulating nuclear hormone receptor activity in mammalian T lymphocytes and Drosophila
Programmed cell homeostasis biological and nuclear hormone receptors and signaling pathways programmed cell death lymphocytes drosophila melanogaster model system
2015/1/28
Regulation of programmed cell death is crucial for proper development and maintaining homeostasis of organisms. This thesis work attempts to elucidate the relationships between two evolutionarily well...
Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells
apoptosis endocycling cells p53 protein
2015/1/7
Apoptotic cell death is an important response to genotoxic stress that prevents oncogenesis. It is known that tissues can differ in their apoptotic response, but molecular mechanisms are little unders...
Conversion of the Bifunctional 8-oxoguanine/β-δ AP DNA Repair Activities of Drosophila Ribosomal Protein S3 into the Human S3 Monofunctional β- elimination Catalyst Through a Single Amino Acid Change
DNA repair drosophila ribosomal protein s3
2014/12/12
The Drosophila S3 ribosomal protein has important roles in both protein translation and DNA repair. In regards to the latter activity, it has been shown that S3 contains vigorous N-glycosylase activit...
Characterization of {\it midline uncoordinated\/}, a mutation affecting behavior and neuroanatomy in Drosophila
Genetics gene gene elements neurons
2014/12/11
Genetic screens which assay behavior have been successfully used to identify genes required for neural function. This thesis is the analysis of midline uncoordinated (muc), a mutation identified for i...
Analysis of programmed cell death in Drosophila
Genes cells activate gene expression system central nervous system cell death protein
2014/12/11
The Drosophila reaper, head involution defective ( hid), and grim genes play key roles in regulating the activation of programmed cell death. In this first part of this study we use the Gal4/UAS targe...
Cloning and characterization of GUKHolder, a novel synaptically expressed protein that interacts with Discs -Large and SCRIBBLE at the Drosophila neuromuscular junction
Neurons spatial arrangement protein tumor protein complex enzyme
2014/12/11
Synaptic transmission between a neuron and its target is crucially dependent upon the precise spatial arrangement of proteins in the pre- and postsynaptic apparatus. PDZ domain-containing proteins suc...
Formation and plasticity of glutamatergic synapses: Characterization of the roles of beta-amyloid precursor protein, scribble, and wingless at the Drosophila neuromuscular junction
Neurons circuit static core
2014/12/11
The flow of information through neuronal circuits relies on the ability of neurons to form synaptic connections with specific temporal and spatial properties. These properties are not static but have ...
Drosophila Wnt-1/Wingless undergoes a hydrophobic modification and is targeted to lipid rafts for secretion, a process that requires Porcupine
Glycoprotein organisms form factor cell and developmental biology acyl transferase
2014/12/11
Wnt ligands are a family of highly conserved glycoproteins that act as morphogens to regulate development in many organisms. Drosophila Wnt-1 (Wingless) is involved in directing cell fate decisions an...
Postsynaptic mechanisms during synaptic plasticity at the Drosophila neuromuscular junction
Synaptic plasticity cells molecules cells nerve muscle
2014/12/11
The ability of established synaptic connections to strengthen and weaken (synapse plasticity) underlies higher order behavior such as learning and memory. Several gaps remain in our understanding of t...
Characterization of bendless and interacting partners in Drosophila central synapse formation
Neurons signaling pathways websites molecular nervous system diseases diseases central synapses fiber system the neural network
2014/12/11
Synapses are the functional units of neuronal circuits and the sites of integration for multiple signaling pathways. Understanding the molecular basis of synaptic function is critical to understanding...
The ubiquitin E3 ligase Human Homolog of Drosophila Ariadne-1 (HHARI) is a structural and functional homolog of Parkin and is required for myogenesis
Autosomal genes Parkinson's disease human beings parkinsonism E3 ubiquitin ligase neurons dopaminergic neurons
2014/12/11
Several genes implicated in Parkinson's disease (PD) encode components of the ubiquitin-proteasome pathway. In a specific form of PD (human Autosomal Recessive Juvenile Parkinsonism, AR-JP), loss of f...
Novel developmental functions of the Drosophila SOX gene Dichaete
Cell biology a fertilized egg embryo cell state factor regulation gene subset of mammalian proteins
2014/12/11
All multicellular life begins as a single cell—the fertilised egg, from which the adult organism develops. As a general priniciple, as embryos progess through development, changes in cellular status s...
Target Recognition and Competitive Synaptogenesis in the Drosophila Giant Fiber System
competition Drosophila giant fiber guidance synaptogenesis
2014/12/10
The development of complex neural networks relies on a careful balance of environmental cues to guide and shape both ends of the eventual connection. However, the correct wiring of circuits whose comp...