搜索结果: 1-14 共查到“FOXP2”相关记录14条 . 查询时间(0.255 秒)
Mapping of Human FOXP2 Enhancers Reveals Complex Regulation
The FOXP2 gene mutation molecular neurobiology
2018/3/5
Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional...
Ultrasonic vocalizations of adult male Foxp2-mutant mice:behavioral contexts of arousal and emotion
Adult mice arousal emotional vocalization Foxp2 mutation positive emotion speech disorder ultrasonic vocalization
2016/5/3
Adult mouse ultrasonic vocalizations (USVs) occur in multiple behavioral and stimulus contexts associated with various levels of arousal, emotion and social interaction. Here, in three experiments of ...
The language-related transcription factor FOXP2 is post-translationally modifid with small ubiquitin-like modifirs
language-related transcription factor FOXP2 post-translationally modifid small ubiquitin-like modifirs
2016/5/3
Mutations affecting the transcription factor FOXP2 cause a rare form of severe speech and language disorder. Although it is clear that sufficient FOXP2 expression is crucial for normal brain developme...
The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21WAF1/CIP1 in 143B Osteosarcoma Cell Growth Arrest
Transcription Factor FOXP2 Is Osteosarcoma Cell
2015/12/18
Mutations of the forkhead transcription factor FOXP2 gene have been implicated in inherited
speech-and-language disorders, and specific Foxp2 expression patterns in neuronal populations and neuronal ...
Assessing the effects of common variation in the FOXP2 gene on human brain structure
FOXP2 imaging genetics language transcription factor MRI brain anatomy VBM
2015/5/5
The FOXP2 transcription factor is one of the most well-known genes to have been implicated in developmental speech and language disorders. Rare mutations disrupting the function of this gene have been...
Disruptions of the FOXP2 gene cause a rare speech and language disorder, a discovery that has opened up novel avenues for investigating the relevant neural pathways. FOXP2 shows remarkably high conser...
FOXP2 Targets Show Evidence of Positive Selection in European Populations
FOXP2 Evidence of Positive Selection European Populations
2015/4/24
Forkhead box P2 (FOXP2) is a highly conserved transcription factor that has been implicated in human speech and language disorders and plays important roles in the plasticity of the developing brain. ...
The DISC1 promoter:characterization and regulation by FOXP2
DISC1 promoter characterization and regulation FOXP2
2015/4/21
Disrupted in schizophrenia 1 (DISC1) is a leading candidate susceptibility gene for schizophrenia, bipolar disorder and recurrent major depression, which has been implicated in other psychiatric illne...
Foxp2 Mutations Impair Auditory-Motor Association Learning
Foxp2 Auditory-Motor Association Learning
2015/4/20
Heterozygous mutations of the human FOXP2 transcription factor gene cause the best-described examples of monogenic speech and language disorders. Acquisition of proficient spoken language involves aud...
An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning
Foxp2 in vivo recording KE family motor-skill learning speech and language striatum
2015/4/20
Mutations in the human FOXP2 gene cause impaired speech development and linguistic deficits, which have been best characterised in a large pedigree called the KE family. The encoded protein is highly ...
Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex
Molecular networks implicated speech-related disorders FOXP2 regulates SRPX2/uPAR complex
2015/4/9
It is a challenge to identify the molecular networks contributing to the neural basis of human speech. Mutations in transcription factor FOXP2 cause difficulties mastering fluent speech (developmental...
The structure of innate vocalizations in Foxp2-deficient mouse pups
Acoustical communication Foxp2 mutation instinctive vocalizing motor control mouse calls speech disorder vocalization deficits
2015/4/8
Heterozygous mutations of the human FOXP2 gene are implicated in a severe speech and language disorder. Aetiological mutations of murine Foxp2 yield abnormal synaptic plasticity and impaired motorskil...
FOXP2基因是人类发现的第一个与语言相关的基因。自其被发现二十多年来,它已经成为国外有关语言神经生物学和生物语言学研究的前言热点。本文根据FOXP2与语言相关性研究的历程和现状以及Kate Distin的模因观或文化DNA假说,初步分析了语言的起源、习得和进化过程。在此基础上,文章对Chomsky的"普遍语法"提出了一些质疑。