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High Bone Mass in Mice Lacking Cx37 Due to Defective Osteoclast Differentiation
gap junctions connexin37 osteoclast
2014/12/4
Connexin (Cx) proteins are essential for cell differentiation, function and survival in all tissues with Cx43 being the most studied in bone. We now report that Cx37, another member of the connexin fa...
Of mice, not men（图）
mice Brain function medical
2014/12/1
For more than a century, the laboratory mouse (Mus musculus) has stood in for humans in experiments ranging from deciphering disease and brain function to explaining social behaviors and the nature of...
Exercise-Induced Changes in the Cortical Bone of Growing Mice Are Bone and Gender Specific
mechanical properties pQCT matrix changes
2014/11/6
Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone's mechanical environment. Male mice have a greater response to no...
Short-Term Exercise In Mice Increases Tibial Post-Yield Mechanical Properties While Two Weeks of Latency Following Exercise Increases Tissue-Level Strength
running mechanical properties histomorphometry extracellular matrix
2014/11/6
We have previously shown that exercise during growth increases post-yield deformation in C57BL6/129 (B6;129) male tibiae at the expense of reduced pre-yield deformation and structural and tissue stren...
Inbred Strain-Specific Effects of Exercise in Wild Type and Biglycan Deficient Mice
Transgenic Mechanical properties Exercise Micro CT Raman
2014/11/6
Biglycan (bgn)-deficient mice (KO) have defective osteoblasts which lead to changes in the amount and quality of bone. Altered tissue strength in C57BL6/129 (B6;129) KO mice, a property which is indep...
Inbred Strain-Specific Response to Biglycan Deficiency in the Cortical Bone of C57BL6/129 and C3H/He Mice
inbred mice mech anical properties mCT PCR Raman histomorphometry
2014/11/6
Inbred strain-specific differences in mice exist in bone cross-sectional geometry, mechanical properties, and indices of bone formation. Inbred strain-specific responses to external stimuli also exist...
High Bone Mass in Mice Lacking Cx37 Due to Defective Osteoclast Differentiation
gap junctions connexin37 osteoclast
2014/11/6
Connexin (Cx) proteins are essential for cell differentiation, function and survival in all tissues with Cx43 being the most studied in bone. We now report that Cx37, another member of the connexin fa...
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice
podosome organization bone density osteoclast functions
2014/11/6
The protein tyrosine kinase Pyk2 is highly expressed in osteoclasts, where it is primarily localized in podosomes. Deletion of Pyk2 in mice leads to mild osteopetrosis due to impairment in osteoclast ...
Engraftment of bone marrow-derived cells after nonlethal radiation in syngeneic C57BL/6 mice
Chimerism Bone marrow-derived cells Nonlethal radiation
2015/11/24
To study the characteristics of cell engraftment in mice at a lower dose under nonlethal radiated condition.Methods A syngeneic C57BL/6 mouse model, transplanted with 1×107 bone marrow cells and expos...
Fibronectin Regulation by Vitamin C Treatment in Kidneys of Nicotinic Mice Offspring
Vitamin C Nicotine Fibronectin Kidney
2015/10/13
Background: Maternal cigarette smoking causes health risks and developmental defects in the offspring. So far, many studies have been conducted to suppress the effects of nicotine. However, the effect...
Melatonin and Testicular Damage in Busulfan Treated Mice
Melatonin Spermatogenesis Busulfan Mice Testis
2015/10/10
Background:: Advancement in the treatment of various types of cancer has led to greater patient survival. These treatments essentially have toxic effects on different kinds of cells, such as germ cell...
Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
Osteoprogenitor Estrogen depletion
2015/5/21
We have shown that nuclear matrix protein 4 (Nmp4) attenuates the response to intermittent parathyroid hormone (PTH) in healthy and ovariectomized (OVX) female mice using a global knockout of the Nmp4...
Scientists from USC and NYU design a molecule that blocks cancer growth in mice
Scientists from USC NYU design a molecule blocks cancer growth in mice
2014/6/12
A team of researchers from USC and NYU has developed and patented a small molecule that interferes with cancer progression with minimal side effects.
The molecule prevents two critical proteins from ...
Mice give ticks a free lunch-Amplifying Risk of Lyme Disease and Other Tick-Borne Ailments
Mice free lunch Risk of Lyme Disease Other Tick-Borne Ailments
2014/3/28
(Millbrook, NY) People living in northern and central parts of the U.S. are more likely to contract Lyme disease and other tick-borne ailments when white-footed mice are abundant. Mice are effective a...
Toxoplasmosis:Experimental Vaginal Infection in NMRI Mice and Its Effect on Uterin, Placenta and Fetus Tissues
Infection Toxoplasma Vaginal NMRI Mice
2015/10/8
Background: Toxoplasma gondii is an important zoonotic pathogen. Vertical transmission of the parasite occurs when females were infected primarily during gestation. This parasite is transmitted to the...