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Influenza Virus-like Particle Containing Two Different Subtypes of Hemagglutinin Confers Protection in Mice Against Lethal Challenge With A/PR8 (H1N1) and A/HK (H3N2) Viruses
Orthomyxoviridae Virus-like particles Influenza Vaccines
2015/9/29
Background: Preventing the seasonal or pandemic outbreak of influenza can be powerful and cost-effective.
Metabolic Adaptations in the Liver of Born Long-Distance Running Mice
PPAR DELTA SIRTUIN 1 LIVER METABOLISM GLUCONEOGENESIS, LIPOGENESIS
2017/7/17
Purpose: Long-distance runners have increased needs of energy supply. To unravel genetically based mechanisms required for efficient energy supply, we have analyzed hepatic metabolism of mice characte...
Synergistic effects of Isatis tinctoria L. and tacrolimus in the prevention of acute heart rejection in mice
satis tinctoria L mice
2013/6/26
Although immunosuppressive treatments are available for acute cardiac rejection no viable treatment exists for long-term cardiac graft failure. Moreover, the extended use of calcineurin inhibitor immu...
Oral Quercetin Supplementation Lowers Plasma sICAM-1 Concentrations in Female db/db Mice
Quercetin Inflammation Insulin Resistance Obesity Adiponectin
2013/2/19
Background: Flavonoids are documented for their potential anti-adipogenic, anti-inflammatory and anti-diabetic effects. Quercetin, one of the most abundant flavonoids in edible plants, was investigate...
Ergogenic Capacity of a 7-Chinese Traditional Medicine Extract in Aged Mice
Antifatigue Antioxidant Chinese Traditional Medicine
2013/1/29
The ergogenic properties of a 7-Chinese traditional medicine water extract (Ligustrum lucidum ait, LLA), which is composed of the essences of Lycii fructus, Crataegi fructus, Phyllanthi fructus, Chrys...
Ultrastructural and morphometrical changes of mice ovaries following experimentally induced copper poisoning
Copper poisoning Electron microscopy Morphometry Ovary Mice
2015/9/28
Background: Copper (Cu) is an essential trace element involved in normal reproduction but its overexposure may produce some detrimental effects. The aim of this study was to investigate the effects of...
中国医学科学院实验血液学国家重点实验室程韩忠朝课题组在Cell Transplant期刊上发表"Human umbilical cord mesenchymal stem cells ameliorate mice trinitrobenzene sulfonic acid (TNBS)-induced colitis"
韩忠朝 课题组 Cell Transplant期刊
2012/2/23
中国医学科学院实验血液学国家重点实验室韩忠朝课题组在Cell Transplant期刊上发表"Human umbilical cord mesenchymal stem cells ameliorate mice trinitrobenzene sulfonic acid (TNBS)-induced colitis."
Antinociceptive,Anti-Inflammatory and Acute Toxicity Effects of Juglans Regia L. Leaves in Mice
Juglans regia Hot-plate test Writhing test Xylene induced ear edema test Cotton pellet test Mice
2015/9/22
Background: Juglans regia leaves have been used in folk medicine to alleviate inflammatory diseases. This study investigates the antinociceptive, anti-Inflammatory and acute toxicity effects of Juglan...
Histopathological effects of chronic fluorosis on the liver of mice (Swiss albino)
Chronic fluorosis mouse liver histopathology
2010/10/14
Fluoride intake in high doses has toxic effects on various organs. Chronic fluorosis results in tubular degenerations, inflammation, fibrosis, parenchymatous nephritis, cloudy swellings, and dilations...
Monoclonal antibody treatment to prolong the secondary cardiac allograft survival in alloantigen-primed mice
Monoclonal antibody mice
2013/6/26
We have previously shown that costimulation blockade using a combination of monoclonal antibodies (mAbs) - CTLA4Ig, antibodies to CD154, LFA-1, and OX40L - can induce tolerance of cardiac allografts i...
Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4(+) memory T cells in mice
Rapamycin tacrolimus rejection
2013/6/26
Donor-reactive memory T (Tm) cells undermine transplanted organs more readily than naive T cells. Rapamycin (RAPA) and tacrolimus (FK-506) are current mainstay immunosuppressants used for preventing a...
Suppressing memory T cell activation induces islet allograft tolerance in alloantigen-primed mice." Transpl Int
ctivation induces islet Suppressing memory
2013/6/26
Summary Memory T cells are known to play a key role in prevention of allograft tolerance in alloantigen-primed mice. Here, we used an adoptively transferred memory T cell model and an alloantigen-prim...
Isatis tinctoria L. combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice
Isatis molecules prolongs
2013/6/26
Memory T cells present a unique challenge in transplantation. Although memory T cells express robust immune responses to invading pathogens, they may be resistant to the effects of immunosuppressive t...
Amphiregulin Is Not Essential for Ovalbumin-Induced Acute Airway Inflammation in Mice
amphiregulin asthma EGF IgE mast cells
2010/11/12
Background: The number of amphiregulin (AR)-positive mast cells in the bronchial mucosa and the levels of AR in sputum from asthmatic patients have been reported to be increased. In addition, AR can p...
Development and time-course of bleomycin-induced pulmonary fibrosis in NMRI mice
Pulmonary fibrosis NMRI mice
2010/4/7
Bleomycin-induced pulmonary fibrosis is a widely used experimental model for human lung fibrosis. The severity of fibrosis varies among different strains of mice and investigation on different strains...