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In 1796, English physician Edward Jenner decided to investigate a tale he had often heard — that milkmaids infected with cowpox became immune to smallpox, a much more dangerous affliction. To test thi...
Anti-inflammatory effects of Morphine on Carrageenan induced Hind Paw edema in mice model of acute inflammation
Carrageenan Acute inflammation
2010/1/5
Background: Using the systemic opioids in pain relief has been known during the history. Several evidences indicate that exogenous opioids such as morphine can produce anti-nociceptive effects by inte...
Sex affects the feeling of pain in the mice,possible involvement of nitric oxide
Pain nitric oxide mice
2010/1/5
It has been shown that nitric oxide is a mediator with a major role in pain signaling at the level of dorsal root ganglion neurons of the spinal cord. The main objective of the present study was to el...
Effects of ketamine and magnesium on morphine induced tolerance and dependence in mice
Morphine Tolerance Withdrawal Magnesium Ketamine
2010/1/5
The goal of this study was to evaluate the effects of ketamine and magnesium on prevention of development of morphine tolerance and dependence in mice. In this study different groups of mice received ...
Distribution of I-125-IgG in normal and induced inflammation in mice
Distribution I-125-IgG inflammation mice
2009/12/31
Antibodies are a diverse class of glycoproteins that specially bind with antigen and elicit a number of secondary responses in vivo. Most of the applications of antibodies in basic research diagnosis ...
Nifedipine in the treatment of liver toxicity induced by Acetaminophen overdose in mice
Liver toxicity Nifedipine liver
2009/12/30
Acetaminophen is an analgesic and antipyretic drug, which is widely used by public and poisoning with this drug, is common. One of the most important adverse effects of acetaminophen poisoning is cent...
RELIMINARY STUDIES OF THE EFFECT OF LAVAMISOLE ON THE IMMUNE RESPONSE OF MICE INFECTED WITH LEISHMANIA
LAVAMISOLE IMMUNE RESPONSE MICE INFECTED LEISHMANIA
2009/12/30
The susceptibility of various strains of mice to infection by Leishmania tropica (major) was recently studied in this laboratory. The infection in A/J, C3H, CBA, AKR/J, AKR/CU, and C57B1 mice (the sem...
The effects of Piperine on the jumping induced by Naloxone in Morphine dependent mice
Black pepper Piperine Morphine dependency Analgesia
2009/12/29
Black pepper has been used in traditional medicine as an analgesic. In this investigation, the effects of piperine, an alkaloid derived from black pepper seeds on the jumping induced by naloxone were ...
The adherence and functional properties of mice peritoneal macrophage phagocytic system with Phorbol Myristate Acetate stimulation and Nitroblue Tetrazolium reduction assay
Peritoneal Macrophages PMA stimulation NBT reduction assay
2009/12/29
Introduction: PMA is known to induce the differentiation of monocytes to macrophages. This agent also increases the killing effect of the monocytes/macrophages through oxidative burst and can be used ...
The adherence and functional properties of mice peritoneal macrophage phagocytic system with Phorbol Myristate Acetate stimulation and Nitroblue Tetrazolium reduction assay
Peritoneal Macrophages PMA stimulation NBT reduction assay
2009/12/29
Introduction: PMA is known to induce the differentiation of monocytes to macrophages. This agent also increases the killing effect of the monocytes/macrophages through oxidative burst and can be used ...
A new approach for the induction of vitiligo in mice
Mushroom tyrosinase Human vitiligo Experimental autoimmune vitiligo
2009/12/28
Tyrosinase has been recognized as a major autoantign in human vitiligo. Here we have shown that experimental autoimmune vitiligo can be induced by intradermal injection of mushroom tyrosinase emulsifi...
Comparison of biodistribution of ¹¹¹In-Tropolone leukocytes and 125I-human nonspecific polyclonal IgG in normal and induced inflammation mice for detection of inflammation
Immunoscintigraphy Acid citrate dextrose (ACD) Hydroxy ethyl starch (HES) Immunoglobulin (Ig) Percent injected dose per gram tissue (%ID/g)
2009/12/25
Human nonspecific polyclonal IgG and granulocytes, which accumulate in inflammation foci, were radiolabeled with 125I and ¹¹¹In-Tropolone, respectively. Biodistribution of these two rad...
Analgesic effect of the methanol extract of Erica arborea (L.) in mice using formalin test
Erica arbore MeOH extract Analgesia Formalin test
2009/12/18
Background and the purpose of the study: Erica arborea L. (Ericaceae) has been used in Turkey folk medicine as a diuretic, urinary antiseptic and laxative. However, its other pharmacological effects h...
Pathogenicity Variations of Susceptibility and Resistance to Leishmania major MRHO/IR/75/ER Strain in BALB/c and C57BL/6 mice
Balb/c C57bl/6 Pathogenicity Iran Leishmania major MRHO/IR/75/ER
2009/12/16
Background: To compare the pathogenicity differences in two susceptible Balb/c and resistant C57bl/6 mice infected with Leishmania major MRHO/IR/75/ER as a prevalent strain of zoonotic cutaneous leish...
Purified Aged Garlic Extract Modulates Allergic Airway Inflammation in Balb/c Mice
Aged Garlic extract Allergic airway inflammation IFNγ IgG1 IgE Murine model
2009/12/15
Garlic is known as a potent spice and a medicinal herb with broad therapeutic properties ranging from antibacterial to anticancer and anticoagulant. Our previous studies have shown some immunoregulato...