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Detecting mutations in mixed sample sequencing data using empirical Bayes
Detecting mutations mixed sample sequencing data empirical Bayes
2012/11/23
We develop statistically based methods to detect single nucleotide DNA mutations in next generation sequencing data. Sequencing generates counts of the number of times each base was observed at hundre...
A branching diffusion model of selection: from the neutral Wright-Fisher case to the one including mutations
Diffusions Doob transform killing, branching quasi-stationarity Wright-Fisher model neutral or with mutation selection
2011/10/8
Abstract: We consider diffusion processes x_{t} on the unit interval. Doob-transformation techniques consist of a selection of x_{t}-paths procedure. The law of the transformed process is the one of a...
Splitting trees with neutral Poissonian mutations I: Small families
branching process coalescent point process splitting tree Crump
2010/12/15
We consider a neutral dynamical model of biological diversity, where individuals live and reproduce independently. They have i.i.d. lifetime durations (which are not necessarily exponentially distribu...