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Moderate-to-vigorous physical activity, but not sedentary time, predicts changes in cardiometabolic risk factors in 10-y-old children: the Active Smarter Kids Study
physical activity sedentary time cardiometabolic risk factors
2018/11/16
Recently, Skrede et al. (1) prospectively examined the association of objectively measured sedentary time and subcomponents of physical activity with individual and clustered cardiometabolic risk fact...
2017纤维素酶和其他碳水化合物活性酶高登研究研讨会（The Gordon Research Seminar (GRS) on Cellulases & Other Carbohydrate-Active Enzymes）
2017 纤维素酶和其他碳水化合物活性酶高登研究 研讨会
2017/3/29
The Gordon Research Seminar on Cellulases and Other Carbohydrate-Active Enzymes is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and educat...
2017纤维素酶和其他碳水化合物活性酶戈登学术会议（The 2017 Gordon Research Conference on Cellulases&Other Carbohydrate-Active Enzymes）
2017 纤维素酶和其他碳水化合物活性酶戈登 学术会议
2017/2/13
The enzymes that deconstruct polysaccharides and in particular those of the plant cell wall share structural, mechanistic and evolutionary similarities whether for biofuels production, for digestion o...
In vitro Screening of Essential Oil Active Compounds for Manipulation of Rumen Fermentation and Methane Mitigation
Essential Oil Active Compounds Methane Production Volatile Fatty Acid Production
2016/7/27
The objective of this study was to investigate the effects of 11 active compounds of essential oils (ACEO) on rumen fermentation characteristics and methane production. Two trials were conducted. In t...
Quantum delocalization of protons in the hydrogen-bond network of an enzyme active site
ab initio path integral molecular dynamics enzyme hydrogen bonding nuclear quantum effects proton delocalization
2016/5/25
Enzymes use protein architectures to create highly specialized structural motifs that can greatly enhance the rates of complex chemical transformations. Here, we use experiments, combined with ab init...
Quantitative Dissection of Hydrogen Bond-Mediated Proton Transfer in the Ketosteroid Isomerase Active Site
active site environment computational modeling enzyme catalysis protein electrostatics protein semisynthesis
2016/5/25
Hydrogen bond networks are key elements of protein structure and function but have been challenging to study within the complex protein environment. We have carried out in-depth interrogations of the ...
Quantitative,Directional Measurement of Electric Field Heterogeneity Within an Enzyme Active Site
Quantitative Directional Measurement Electric Field Heterogeneity Enzyme Active Site
2016/5/25
Extensive structural studies of enzymes have revealed that biological catalysis occurs within sequestered active site crevices, where reacting substrates are surrounded by an anisotropic and chemicall...
Solvation Response Along the Reaction Coordinate in the Active Site of Ketosteroid Isomerase
Pseudomonas putida Coumarins Isomerases Spectrometry, Fluorescence Catalytic Domain Ketosteroids Biocatalysis Light Models, Molecular Equilenin
2016/5/25
A light-activated reaction analog has been developed to mimic the catalytic reaction cycle of Delta(5)-3-ketosteroid isomerase to probe the functionally relevant protein solvation response to the cata...
Proton Affinity of the Oxyanion Hole in the Active Site of Ketosteroid Isomerase
Pseudomonas putida Protons Steroid Isomerases Crystallography,X-Ray Nuclear Magnetic Resonance,Biomolecular Catalytic Domain Protein Conformation Substrate Specificity Ketosteroids Mutagenesis, Site-Directed
2016/5/25
The absorption spectra of a series of inhibitors bound at the active site of Delta(5)-3-ketosteroid isomerase from Pseudomonas putida were found to exhibit substantial variations in the contributions ...
Electrostatic Fields Near the Active Site of Human Aldose Reductase:1.New Inhibitors and Vibrational Stark Effect Measurements
apoptosis ATM cisplatin IKK p73 ubiquitination
2016/5/25
Vibrational Stark effect spectroscopy was used to measure electrostatic fields in the hydrophobic region of the active site of human aldose reductase (hALR2). A new hALR2 inhibitor was designed and sy...
Vibrational Dynamics of Carbon Monoxide at the Active Sites of Mutant Heme Proteins
Vibrational Dynamics Carbon Monoxide Active Sites Mutant Heme Proteins
2016/5/23
Picosecond mid-IR pump−probe measurements of vibrational relaxation (VR) of CO bound to the active sites of wild-type and mutant myoglobins (Mb) reveal that an approximately linear relationship ...
Over the last 50 years, international public concern regarding human impact on the environment has increased drastically. Specific to the maritime domain, attention has more acutely focused during the...
The active site chemistry of factor inhibiting HIF-1, coordination, bonding, and reaction
Pure sciences Autohydroxylation Factor inhibiting HIF Iron center coordination
2014/12/10
Oxygen is vital for aerobic life. A shortage of oxygen can produce disastrous outcomes to cellular functions. To avoid this, eukaryotic cells developed an oxygen sensing machinery of which the key com...
Microarray Analysis of Genes Involved with Shell Strength in Layer Shell Gland at the Early Stage of Active Calcification
Chicken Microarray Differentially Expressed Genes Eggshell Strength
2016/5/11
The objective of this study was to get a comprehensive understanding of how genes in chicken shell gland modulate eggshell strength at the early stage of active calcification. Four 32-week old of pure...
Active Brownian motion of an asymmetric rigid particle
Active Brownian motion asymmetric rigid particle Biological Physics
2012/5/17
Individual movements of a rod-like self-propelled particle on a flat substrate are quantified. Biological systems that fit into this description may be the Gram-negative delta-proteobacterium Myxococc...