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In recent years, scientists who study gene expression in cells have used a method that essentially pins a tail on RNA and tracks their whereabouts. However, certain types of RNA evade the process. Now...
Genome-wide identification of NF-YA gene family in cotton and the positive role of GhNF-YA10 and GhNF-YA23 in salt tolerance
全基因组分析 雷蒙德氏棉 亚洲棉 海岛棉 陆地棉
2024/5/17
本研究基于全基因组分析，在雷蒙德氏棉、亚洲棉、海岛棉和陆地棉基因组中分别鉴定得到16、16、31和29个NF-YA基因。通过进化树分析将NF-YA基因分为4个亚组。结构分析表明NF-YA基因在棉属进化过程中相对保守。荧光定量显示GhNF-YAs可能通过ABA和 MeJA的调控通路响应盐和干旱。VIGS沉默GhNF-YA10和GhNF-YA23的表达，能显著降低棉花对盐的抗性，表明这两个基...
The role of transcriptome resilience in resistance of corals to bleaching
heat stress coral bleaching transcriptomics resilience gene expression
2015/12/11
Wild populations increasingly experience extreme conditions as climate change
amplifies environmental variability. How individuals respond to environmental extremes
determines the impact of climat...
HUMAN CARBOXYLESTERASE 2 SPLICE VARIANTS: EXPRESSION, ACTIVITY, AND ROLE IN THE METABOLISM OF IRINOTECAN AND CAPECITABINE
Carboxylesterase alternative splicing colorectal cancer
2015/5/25
Carboxylesterases (CES) are enzymes that metabolize a wide variety of compounds including esters, thioesters, carbamates, and amides. In humans there are three known carboxylesterase genes CES1, CES2,...
ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU80 C-TERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU
DNA-PKcs regulation Ku NHEJ
2015/5/25
DNA double strand breaks (DSB) are among the most lethal forms of DNA damage and can occur as a result of ionizing radiation (IR), radiomimetic agents, endogenous DNA-damaging agents, etc. If left unr...
REGULATION OF CHOP TRANSLATION IN RESPONSE TO eIF2 PHOSPHORYLATION AND ITS ROLE IN CELL FATE
Stress (Physiology) Messenger RNA Apoptosis
2015/5/25
In response to different environmental stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) rapidly reduces protein synthesis, which lowers energy expenditure and facilitates reprogrammi...
The role of pyruvate dehydrogenase kinase in glucose and ketone body metabolism
ketoacidosis hypothermia fatty acid pyruvate carboxylase
2015/5/25
The expression of pyruvate dehydrogenase kinase (PDK) 2 and 4 are increased in the fasted state to inactivate the pyruvate dehydrogenase complex (PDC) by phosphorylation to conserve substrates for glu...
The role of the CTD phosphatase Rrt1 and post-translational modifications in regulation of RNA polymerase II
CTD phosphatase Rtr1 MuDPIT AP-MS
2015/5/25
RNA polymerase II (RNAPII) is regulated by multiple modifications to the C-terminal domain (CTD) of the largest subunit, Rpb1. This study has focused on the relationship between hyperphosphorylation o...
The role of acid sphingomyelinase in autophagy
sensing rapamycin mammalian target of rapamycin
2015/5/25
Phosphatases of regenerating liver, consisting of PRL-1, PRL-2 and PRL-3, belong to a novel protein tyrosine phosphatases subfamily, whose overexpression promotes cell proliferation, migration and inv...
LIM homeodomain 3 (LHX3) is an important regulator of pituitary and nervous system development. To date, twelve LHX3 gene mutations have been identified in patients with combined pituitary hormone def...
The Role of the SUPRMAM1 Locus in Responses to Ionizing Radiation and Susceptibility to Mammary Tumors
Cancer breast cancer genetic spontaneous mammary gland tumor chromosome
2014/12/10
Loss of p53 function can lead to a variety of cancers, including breast cancer. Mice heterozygous for the p53 gene (designated Trp53+/-) develop spontaneous mammary tumors, but this depends on the str...
Potential role of histone deacetylases in the development of the chick and murine retina
Development Epigenetics Retina HDACs
2015/5/22
The epigenetic state of any cell is, in part, regulated by the interaction of DNA with nuclear histones. Histone tails can be modified in a number of ways that impact on the availability of DNA to int...
Role of a putative bacterial lipoprotein in Pseudomonas aeruginosa-mediated cytotoxicity toward airway cells
Pseudomonas aeruginosa infection Cystic Fibrosis Cytotoxicity
2015/5/22
The patients with Cystic fibrosis (CF), an inherent genetic disorder, suffer from chronic bacterial infection in the lung. In CF, modification of epithelial cells leads to alteration of the lung envir...
ROLE OF GENOMIC COPY NUMBER VARIATION IN ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT
Copy number variation Alzheimer's disease
2015/5/21
Alzheimer's disease (AD) is the most common form of dementia defined by loss in memory and cognitive abilities severe enough to interfere significantly with daily life activities. Amnestic mild cognit...
Better Beef and Milk Through Nuclear Research--IAEA Had Key Role in Global Effort to Characterize Complete Bovine Genome
Beef and Milk Nuclear Research Key Role Global Effort Bovine Genome
2009/6/5
Cattle breeders are now able to screen and select cattle for specific features, such as the ability to produce high-quality milk or resist specific diseases. After six years of work by more than 300 r...