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Opportunities and challenges with CRISPR-Cas mediated homologous recombination based precise editing in plants and animals
CRISPR-Cas Homology directed repair (HDR) Non-homologous end joining (NHEJ) Knock-in Gemini virus replicon (GVR) Gene targeting (GT)
2023/11/16
The genome editing has revolutionized the agriculture and human therapeutic sectors by its ability to create precise, stable and predictable mutations in the genome. It depends upon targeted double-st...
LSD1-LIKE1-mediated H3K4me2 demethylation is required for homologous recombination repair
H3K4me2 genome stability LYSINE-SPECIFIC DEMETHYLASE1-LIKE1 homologous recombination
2024/2/29
Homologous recombination is a key process for maintaining genome integrity and diversity. In eukaryotes, the nucleosome structure of chromatin inhibits the progression of homologous recombination. The...