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Synthesis of 13C-Labeled Ubiquinone-Acetogenin Hybrid Inhibitors of Mitochondrial Complex I
mitochondrial complex I acetogenin ubiquinone
2009/3/6
Natural acetogenins are the most potent inhibitors of mitochondrial complex I. By synthesizing a ubiquinone-acetogenin hybrid inhibitor (named Q-acetogenin), we previously showed that a γ-lactone ri...
Synthesis of photolabile Δlac-acetogenin for photoaffinity labeling of mitochondrial complex I
complex I acetogenin respiratory inhibitor
2009/3/5
Δlac-Acetogenins are a novel type of inhibitor acting at the terminal electron transfer step of mitochondrial NADH-ubiquinone oxidoreductase (complex I). To identify the binding site of Δlac-acetogeni...