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The DNA in our cells constantly changes its structure and chemical composition in the course of endogenous processes and in response to exogenous challenges. The 2017 Mammalian DNA Repair GRC will exp...
2017组织修复和再生戈登学术会议（The 2017 Gordon Research Conference on Tissue Repair & Regeneration）
Tissue Repair Regeneration
2017/1/18
Deregulation of normal tissue repair has dramatic consequences for life quality and survival of patients. Together, insufficient healing (chronic wounds) and excessive repair after injury (scarring/fi...
2017肺发育，损伤和修复戈登学术会议（The 2017 Gordon Research Conference on Lung Development, Injury & Repair）
Lung Environmental Changes
2017/1/13
Chronic pulmonary diseases frequently develop in the context of the aging lung and in response to a permanent interaction of the bronchial and alveolar epithelium with inhaled agents, allergens and no...
Polina Anikeeva hopes to one day be able to regenerate the spinal cord to restore movement for paralyzed people or possibly bypass the spinal cord altogether with a device that mimics its function.
Penn-Engineered Neural Networks Show Hope for Axonal Repair in the Brain,with Minimal Disruption to Brain Tissue
Penn-Engineered Neural Networks Show Axonal Repair in the Brain Minimal Disruption to Brain Tissue
2016/2/22
Lab-grown neural networks have the ability to replace lost axonal tracks in the brains of patients with severe head injuries, strokes or neurodegenerative diseases and can be safely delivered with min...
Arrhythmias After Tetralogy of Fallot Repair
Tetralogy of Fallot surgery ventricular arrhythmias risk stratification
2015/7/29
Tetralogy of Fallot is the most common cyanotic congenital heart disease, with a good outcome after total surgical correction. In spite of a low perioperative mortality and a good quality of life, lat...
Breakage and missing of the episiotomy needle is not uncommon occurrence at the hands of the junior doctors. Retrieving it from deeper tissue planes following its migration can be a challenging task.
Breakage and missing of the episiotomy needle is not uncommon occurrence at the hands of the junior doctors. Retrieving it from deeper tissue planes following its migration can be a challenging task.
A comparison between the effects of three potential scar-reducing agents applied at a site of sciatic nerve repair
Peripheral Nerve Repair Nerve Regeneration Scarring Triamcinolone Acetonide
2015/7/22
We have investigated the effect of three potential scar-reducing agents applied at a sciatic nerve repair site in C57-black-6 mice. Under anaesthesia the nerve was transected, repaired using four epin...
Inhibition of Ape1's DNA Repair Activity as a Target in Cancer: Identification of Novel Small Molecules that have Translational Potential for Molecularly Targeted Cancer Therapy
Cancer Chemotherapy Base Excision Repair DNA Repair
2015/5/25
The DNA Base Excision Repair (BER) pathway repairs DNA damaged by endogenous and exogenous agents including chemotherapeutic agents. Removal of the damaged base by a DNA glycosylase creates an apurini...
The Effectiveness of Electromyographic Biofeedback as Part of a Meniscal Repair Rehabilitation Programme
Knee injury physical therapy
2015/5/18
The objective of the study was to assess the effectiveness of using electromyographic biofeedback in the early stages of rehabilitation after meniscal repair. In this randomised, controlled, parallel ...
Regulation of Muscle Glycogen Repletion, Muscle Protein Synthesis and Repair Following Exercise
Carbohydrate nutrients insulin glucose amino acids
2015/3/13
Recovery from prolonged strenuous exercise requires that depleted fuel stores be replenished, that damaged tissue be repaired and that training adaptations be initiated. Critical to these processes ar...
Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1
APE1/Ref-1 redox signaling cancer
2014/12/12
The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of th...
Role of Ape1 and Base Excision Repair in the Radiation Response and Heat-radiosensitization of HeLa Cells
radiation hyperthermia DNA repair
2014/12/12
Background: The mechanism by which heat sensitizes mammalian cells to ionizing radiation remains to be elucidated. We determined whether base excision repair (BER) is involved in heat-radiosensitizati...