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非酒精性脂肪性肝病（NAFLD）是全球发病率最高的慢性肝病，目前仍缺乏有效的治疗手段。NAFLD包括单纯性脂肪肝和非酒精性脂肪性肝炎（NASH），后者是一种更为严重的代谢性肝病，可以增加肝细胞癌的发生率。
厦门大学生命科学学院周大旺课题组在《Developmental Cell》上揭示肝肠循环因子FGF15/19通过Hippo信号通路调节胆汁酸代谢从而控制肝脏再生与尺寸大小（图）
厦门大学生命科学学院 周大旺 肝肠 循环因子 FGF15/19 Hippo信号通路 胆汁酸代谢 肝脏
2019/2/27
众所周知，肝脏是人体的一个重要的代谢器官，而它的大小相对于整个个体大小始终维持在一个合适的比例，即使在损伤或部分切除后，肝脏仍能通过一系列精细的再生调控过程恢复到正常大小。肝脏如何感知生长起始和停止是肝脏发育、再生以及癌症生物学中一个仍有待解决的基本科学问题。近年来研发现Hippo信号通路在从果蝇到哺乳动物个体的器官发育及大小调控中都起着至关重要的作用。在小鼠肝脏中特异性敲除或失活Hippo通路中...
北京大学分子医学研究所刘颖课题组在Nature Cell Biology发文报道DNA 6mA调控线粒体胁迫适应性的跨代遗传（图）
北京大学分子医学研究所 刘颖 课题组 DNA 6mA 线粒体 胁迫适应性 跨代遗传
2018/12/6
2018年12月3日，北京大学分子医学研究所、北大-清华生命科学联合中心刘颖课题组在Nature Cell Biology在线发表题为“N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation”的论文，报道秀丽隐杆线虫可以将亲代受到的线粒体胁迫信息通过DNA和...
作为遗传信息功能性解读的一个重要环节，动态修饰调控是中心法则的必要拓展。甲基化作为一种增加所修饰残基特征的生物化学策略，通常被细胞用于识别和调控。提及蛋白质甲基化，人们较为熟知的是赖氨酸或精氨酸甲基化；其实，组氨酰肽或蛋白质组氨酸也可以发生甲基化，比如肌肽（carnosine），核糖体蛋白Rpl3和肌动蛋白等。组氨酸甲基化可以发生在侧链咪唑环的N1位或N3位，这种位置特异性是由不同家族的组氨酸甲基...
中国医学科学院北京协和医学院基础医学研究所余佳研究团队在《Cell Research》杂志发表文章揭示miRNA加工调节新元件及机理（图）
中国医学科学院北京协和医学院基础医学研究所 余佳研究团队 miRNA加工 元件机理 造血发育
2017/12/15
miRNA是众多非编码RNA分子中研究较早，也较为深入的一类，其通过与靶标基因3’UTR的配对，调节靶标基因mRNA的稳定性或翻译，从而参与细胞命运决定、个体发育及疾病发生等众多生理病理过程。相对于miRNA的靶基因及其作用的下游通路，其自身的生物发生过程及调控环节仍知之较少。目前所知，除经典的Drosha-Dicer通路外，也发现了不依赖于Drosha（如：mirtron、endo-shRNA-...
Mol Cell—浙江大学医学院刘伟实验室揭示自噬调控新机制
Mol Cell 浙江大学医学院 刘伟实验室 自噬调控新机制
2017/10/23
近日，Molecular Cell杂志在线发表来自浙江大学医学院刘伟教授实验室题为“mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis”的研究论文。这是他们继上月发表了“VPS34 Acetylation Controls Its Lipid Kinase Activity and t...
Construction of Recombinant Bacmid Containing M2e-Ctxb and Producing the Fusion Protein in Insect Cell Lines
Influenza Vaccines Baculovirus Cholera Toxin Subunit B
2015/10/10
Background:: Sequence variations in glycoproteins of influenza virus surface impel us to design new candidate vaccines yearly. Ectodomain of influenza M2 protein is a surface and highly conserved prot...
近日，纽约大学Langone医学中心研究人员发现致命的金黄色葡萄球菌攻击并杀死免疫细胞的一种新机制。
Effect of Pentoxifylline Administration on Mast Cell Numbers and Degranulation in a Diabetic and Normoglycemic rat Model Wound Healing
Pentoxifylline Mast cells Diabetes Mellitus Wound Healing
2015/9/28
Background: Wound healing is a complicated and integrated process. Researches in the molecular level on human and animal models have indicated several molecular changes related to the effect of diabet...
A GENETIC STUDY OF IRANIAN POPULATIONS: RED CELL ENZYMES
Red cell enzymes phosphoglucomutase
2009/12/29
A total of 1695 blood samples collected from ten ethnically distinct populations of Iran (Turks and Kurds of Rezaieh, Lurs, Aabolis, Baluchis, Turks and Kurds of Shrvan, Zoroastrians, Tehranis, and Ke...
Screening of prognostic factors using multiplex RT-PCR technique on different leukemic cell lines
Multiplex RT-PCR T-ALL oncogene leukemia cell
2009/12/18
Background: Leukemia is one of the most common pediatric malignancies. T-cell Acute Lymphoblastic Leukemia (T-ALL) accounts for 15% of hematopoetic cancers. It has been well understood that identifica...
The Effects of Sodium Selenite on the Antioxidative Defence Mechanism of Human Hepatoma G2 Cell
Hepatoma G2 Sodium selenite Glutathione peroxidase Catalase Superoxide dismutase
2009/6/30
Human cells that live in biological harmony can become cancerous. As they do so, they engage in anaerobic respiration, undergo rapid cell growth and division according to nonmitotic rules, and importa...
Analysis of Cell-Free Fetal DNA from Maternal Plasma and Serum Using a Conventional Multiplex PCR:Factors Influencing Success
Noninvasive prenatal diagnosis maternal plasma maternal serum fetal gender determination conventional multiplex PCR
2009/6/23
Recent technology enables the use of cell-free fetal DNA in maternal plasma and serum for noninvasive prenatal genetic diagnosis. This study was designed to evaluate factors most likely to influence t...
Recognition of T Cell Epitopes Unique to Cha o 2, the Major Allergen in Japanese Cypress Pollen, in Allergic Patients Cross-Reactive to Japanese Cedar and Japanese Cypress Pollen
Cha o 2 cross-reactivity Cry j 2 pollinosis T cell epitope
2010/11/16
Background: Pollens from species of the Cupressaceae family are one of the most important causes of respiratory allergies worldwide. Many patients with pollinosis have specific IgE to both allergens f...
Dendritic Cells Bearing HLA-G Inhibit T-Cell Activation in Type 1 Diabetes
Dendritic cell HLA-G IFN-β (Interferon β)
2010/4/2
HLA-G is normally expressed on human trophoblast cells. It is a non-classical MHC molecule class I b. The role of HLA-G in diabetic type 1 is not known.We investigated the role of IFN-β in induction H...