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Testosterone feedback on gonadotropin secretion and gene expression in transgenic mice expressing human growth hormone gene
Luteinizing hormone follicle-stimulating hormone
2009/2/12
To determine the effects of testosterone on the regulation of gonadotropins in metallothionein-1/human growth hormone (MT/hGH) transgenic mice, basal and gonadotropin-releasing hormone (GnRH)-stim...
Impairment of spermatogenesis in transgenic mice with selective overexpression of Bcl-2 in the somatic cells of the testis
Apoptosis Bax Sertoli cell Leydig cell endocrine dysfunction
2008/12/29
To explore the functional role of Bcl-2 in germ cell development, transgenic mice carrying 6 kilobases of the inhibin-alpha promoter were generated to express human bcl-2 gene product in the gona...
Overexpression of Endothelial Nitric Oxide Synthase in Transgenic Mice Accelerates Testicular Germ Cell Apoptosis Induced by Experimental Cryptorchidism
Immunoblotting TUNEL spermatocytes spermatids spermatogonia
2008/12/23
Surgical induction of cryptorchidism in experimental animals causes testicular germ cell apoptosis and infertility. The mechanisms of germ cell apoptosis have been associated with oxidative stress o...
Recapitulation of Germ Cell- and Pituitary-Specific Expression With 1.6 kb of the Cystatin-Related Epididymal Spermatogenic（Cres）Gene Promoter in Transgenic Mice
Epididymis testis spermatogenesis gene regulation
2008/12/23
The Cres (cystatin-related epididymal spermatogenic) gene encodes the defining member of a new subgroup within the family 2 cystatins of cysteine protease inhibitors. Cres expression is highly tis...
Effects of Putative Epididymal Osmolytes on Sperm Volume Regulation of Fertile and Infertile c-ros Transgenic Mice
Sperm swelling regulatory volume decrease quinine organic osmolytes infertility
2008/12/22
Volume regulation by spermatozoa has been demonstrated to be crucial in both mice and men for transport in the female tract. In order to determine the nature of osmolytes used by spermatozoa, they...
Immortalized Epididymal Cell Lines From Transgenic Mice Overexpressing Temperature-Sensitive Simian Virus 40 Large T-Antigen Gene
Epididymis immortalized cell line transgenic mouse SV40T-antigen
2008/12/16
Epididymal epithelium is well known as a site of secretion of various proteins present in epididymal luminal fluid. Although there have been many reports of primary cultures of epididymal epithelial c...