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Identification, kinetic and structural characterization of small molecule inhibitors of aldehyde dehydrogenase 3a1 (Aldh3a1) as an adjuvant therapy for reversing cancer chemo-resistance
cyclophosphamide chemosensitivity structure activity relationships cell culture
2015/5/25
ALDH isoenzymes are known to impact the sensitivity of certain neoplastic cells toward cyclophosphamides and its analogs. Despite its bone marrow toxicity, cyclophos-phamide is still used to treat var...
Patients with resected colon cancer (stage III [T1 to T4, N1-N2] or high-risk stage II [T3 or T4, N0]) or stage II/III rectal cancers (T3 or T4, N0-2) are at significant risk of local and distant fail...
Local therapy in a systemic world: the evolution and incarnations of adjuvant radiotherapy for breast cancer
Local therapy in a systemic world the evolution and incarnations adjuvant radiotherapy breast cancer
2015/3/23
Alan Coates’ career has seen the evolution of radiotherapy in the adjuvant treatment of breast cancer move from the only modality available, through a period of little utilisation, to its current resu...
The effect of adjuvant chemotherapy on cognitive functioning in early breast cancer: implications for outcomes research and oncology practice
cognitive functioning early breast cancer outcomes research oncology practice
2015/3/19
Outcomes research is an important focus of public and research policy in Australia. Recent reports of cognitive impairment after chemotherapy for breast cancer have highlighted the emerging importance...
Analysis of the Effect of Radiotherapy on Malignant Pleural Mesothelioma when Given on Adjuvant or Palliative Basis
Maligant Pleural Mesothelioma Radiotherapy
2013/12/9
Background and objective This retrospective study was designed to evaluate the response and survival of malignant pleural mesothelioma to radiotherapy when delivered with surgery and chemotherapy and ...
Analysis of the Effect of Radiotherapy on Malignant Pleural Mesothelioma when Given on Adjuvant or Palliative Basis
Maligant Pleural Mesothelioma Radiotherapy
2013/12/9
Background and objective This retrospective study was designed to evaluate the response and survival of malignant pleural mesothelioma to radiotherapy when delivered with surgery and chemotherapy and ...