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Interest has increased in understanding the interaction between
genes and nutrients in the development of atherosclerosis (1).
Many studies have addressed the role of such interactions in the
respo...
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
folate homocysteine mutation
2016/6/1
Down syndrome, or trisomy 21, is a complex
genetic disease resulting from the presence of 3 copies of chromosome
21. The origin of the extra chromosome is maternal in
95% of cases and is due to the...
Folate and homocysteine metabolism and gene polymorphisms in the etiology of Down syndrome
homocysteine metabolism gene polymorphisms
2016/6/1
One of the major advances in preventing malformations in the
past few decades had its origin in the observation by Smithells et
al (1) that multivitamin preparations are protective against neural
t...
Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein
Retinol binding protein transthyretin retinol retinyl esters
2016/5/31
Two German sisters aged 14 and 17 y were admitted
to the Tübingen eye hospital with a history of night blindness.
In both siblings, plasma retinol binding protein (RBP) concentrations
were below th...
Mutations in the gene encoding retinol binding protein and retinol deficiency: is there compensation by retinyl esters and retinoic acid?
retinyl esters retinoic acid
2016/5/31
Biesalski et al (1) present a novel case of 2 sisters aged 14 and
17 y with very low plasma retinol concentrations (0.19 mmol/L)
and plasma concentrations of retinol binding protein (RBP) below
the...
HISTONE DEACETYLASE INHIBITORS TRICHOSTATIN A (TSA) AND SULFORAPHANE (SFN) MODULATE VITAMIN D RESPONSIVE CYP24 GENE EXPRESSION in 3T3-L1 PREADIPOCYTES
TRICHOSTATIN A (TSA) SULFORAPHANE (SFN), CYP24 3T3-L1 PREADIPOCYTES
2014/11/7
Vitamin D plays an important role in preserving healthy bones, and has additional roles in the body, including modulation of cell growth, differentiation, neuromuscular and immune function, and anti-i...
Ala12 variant of the peroxisome proliferator-activated receptor- gene（PPARG）is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial infarction
Cardiovascular disease peroxisome proliferatoractivated receptor- PPARG polyunsaturated fatty acids
2008/12/25
Background: Intake of polyunsaturated fat is protective against the development of coronary heart disease. Less is known about the genetic variation modulating this association. The Ala12 allele of th...
Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women
Eating disorders ghrelin body mass index body dissatisfaction polymorphisms obesity
2008/12/17
Background: Ghrelin is an endogenous peptide that stimulates growth hormone secretion, enhances appetite, and increases body weight and may play a role in eating disorders.Objective: The purpose was t...
Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Québec Family Study1,2,3
Adiponectin adiponectin receptor resting metabolic rate respiratory quotient obesity abdominal obesity
2008/12/12
Background: Despite adiponectin's presumed role in fatty acid oxidation and energy homeostasis, little is known about the effect of gene variants on substrate oxidation, energy expenditure, and adipos...
Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT Study
Gene-nutrient interactions metabolic syndrome insulin resistance microarray adipose tissue
2008/12/12
Background: Diets rich in whole-grain cereals and foods with a low glycemic index may protect against type 2 diabetes, but the underlying molecular mechanisms are unknown.Objective: The main objective...
-Linolenic acid, 6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction1,2,3
Myocardial infarction genetics diet fatty acids epidemiology
2008/12/12
Background:6-Desaturase (FADS2) is the rate-limiting step in the polyunsaturated fatty acid (PUFA) biosynthetic pathway.Objective:The aim was to test whether the common deletion [T/-] in the promoter ...
Effect of the maternal ßE-globin gene on hematologic responses to iron supplementation during pregnancy1,2,3
Hemoglobin E iron supplementation thalassemia serum ferritin pregnancy
2008/12/11
Background: It is customary in Southeast Asia to treat pregnant anemic women with iron supplements, but anemia in this region may be complicated by thalassemia and hemoglobinopathies, which lead to an...
Polymorphism exon 1 variant at the locus of the scavenger receptor class B type I gene: influence on plasma LDL cholesterol in healthy subjects during the consumption of diets with different fat contents
dietary intervention LDL cholesterol genetic polymorphism
2016/12/30
The objective of the study was to determine whether the exon 1 variant (G→A) at the SRB-I gene is associated with the lipid response to the content and quality of dietary fat in healthy subjects.
A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle
skeletal muscle metabolism dietary intervention
2016/12/28
The objective was to determine the effect of altered dietary fat intake on the expression of genes encoding proteins necessary for fatty acid transport and β-oxidation in skeletal muscle.
Rapid westernization of children’s blood cholesterol in 3 countries: evidence for nutrient-gene interactions?
Cholesterol dietary fat children heart disease Japan Spain Hegsted equation
2016/6/8
The aim of this study was to examine potential
factors that modify blood cholesterol among children in countries
in which dietary and lifestyle habits are becoming westernized.
Population data on s...