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ELUCIDATING MECHANISMS THAT LEAD TO PERSISTENT ANXIETY-LIKE BEHAVIOR IN RATS FOLLOWING REPEATED ACTIVATION OF CORTICOTROPIN-RELEASING FACTOR RECEPTORS IN THE BASOLATERAL AMYGDALA
anxiety corticotropin-releasing factor somatostatin amygdala basolateral amygdala
2015/5/21
Anxiety disorders are estimated to impact 1 in 4 individuals within their lifetime. For some individuals, repeated episodes of the stress response leads to pathological anxiety and depression. The str...
OPRT Is a Potential Predictive Factor for the Response to S-1 in Gastric Cancer
S-1 Chemotherapy Gastric Cancer Orotate Phosphoribosyltransferase Biomarker
2013/1/30
Objective: To analyze the impact of mRNA expression of oral fluoropyrimidine (S-1) metabolism (thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosy...
The LysR Transcription Factor, HexS, Is Required for Glucose Inhibition of Prodigiosin Production by Serratia marcescens
Pigment Antibiotic Transcription Factor Secondary Metabolite
2013/1/29
Generation of many useful microbe-derived secondary metabolites, including the red pigment prodigiosin of the bacterium Serratia marcescens, is inhibited by glucose. In a previous report, a genetic ap...
Growth and differentiation factor-11 is developmentally regulated in skeletal muscle and inhibits myoblast differentiation
GDF-11 Developmental Expression Post-Natal Muscle Growth Sexual Dimorphism Myoblast Differentiation
2013/1/30
Growth and differentiation factor-11 (GDF-11) is a secreted protein that is closely related to myostatin, a known inhibitor of skeletal muscle development. The role of GDF-11 in regulating skeletal mu...
Immunohistochemical Evaluation of Vascular Endothelial Growth Factor (VEGF) in Splenic Hemangiomas and Hemangiosarcomas in Dogs
Canine Spleen Angiogenesis Hemangiosarcoma Immunohistochemistry
2013/2/19
Formation of new blood vessels is paramount for tumour growth and metastatic dissemination and vascular endothelial growth factor (VEGF) is one of the key regulators of this process. The purpose of th...
Extraction of Transcription Factor Networks via Globally Optimal Biclustering
Bi-clustering Transcription Network Reconstruction
2009/12/24
We present an optimization-based framework for identifying and quantifying interactions transcription factor networks. We explore the availability of high-temporal resolution expression data using the...
Pneumococcal serotypes recovered from health children and their possible association with risk factor in Istanbul, Turkey
Streptococcus pneumoniae colonization vaccine
2009/10/30
Streptococcus pneumonia is an increasing problem worldwide and nasopharyngeal colonization plays an important role in pneumococcal infections. The aims of this study were to assess the nasopharyngeal ...
A Common Polymorphism of Upstream Transcription Factor 1 Gene is associated with Lipid Profile: A Study in Chinese Type 2 Diabetes Families
dyslipidemia genetic epidemiology single nucleotide polymorphism type 2 diabetes mellitus upstream transcription factor
2009/10/30
Upstream transcription factor 1 (USF1) is capable of controlling various members in glucose and lipid metabolism pathways. Much evidence suggests that the rs3737787 polymorphism in the USF1 gene may l...
CAE Stress Field Analysis by Shape Factor of Artificial Organs for Aortic Root Replacement
Aortic valve Valsalva sinus artificial valve CAD/CAE
2009/8/24
The sinuses of Valsalva are known to contribute to the normal function. Therefore, the Valsalva graft is being widely used in the aortic root replacement. On the other hand, the artificial valve is de...
Stem cell factor induces heterotopic accumulation of cells（heterotopia）in the mouse cerebral cortex
Stem cell factor heterotopic accumulation of cells (heterotopia) mouse cerebral cortex
2009/5/8
The stem cell factor (SCF)-c-kit signal transduction pathway plays an important role in the proliferation and migration of neural progenitor cells, but little is known about its function during the ...
Retroperitoneal Hemorrhage from Adrenocortical Carcinoma as a Poor Prognostic Factor
adrenal cancer retroperitoneal hemorrhage steroids
2009/4/29
In most patients, adrenocortical carcinoma is diagnosed at an advanced stage of the disease. A sudden retroperitoneal hemorrhage may sometimes be the first symptom of the adrenal cancer. We describe f...
Panretinal-Photocoagulation before Pars Plana Vitrectomy Influences Vitreous Level of Interleukin-6 but not of Vascular Endothelial Growth Factor in Patients with Diabetic Retinopathy
diabetic retinopathy interleukin-6 (IL-6) panretinal photocoagulation (PRP) pars plana vitrectomy (PPV)
2009/4/20
For eyes with diabetic retinopathy which require vitreous surgery and pan-retinal photocoagulation (PrP), pre-treatment of PrP before vitreous surgery reduce the activity of diabetic retinopathy, ho...
Vanadate-induced expression of hypoxia inducible factor-1α via oxygen-dependent and -independent pathways
HIF-1α vanadium cobalt 17-AAG
2009/4/1
Increase in hypoxia-inducible factor-1α (HIF-1α) expression is caused by some essential trace elements such as vanadium and cobalt even under normoxic conditions. The mechanism of HIF-1α activation ca...
Relationship between tumor necrosis factor-alpha (TNF) profile and urinary tract pathology in rural Nigerians with Schistosoma haematobium infection
Schistosoma haematobium Tumor necrosis factor
2010/12/10
Schistosomiasis is estimated to affect more than 200 million people especially in rural and agricultural areas. Schistosoma haematobium causes significant urinary tract diseases and is mediated by T c...
The Effects of Dibutyltin(DBT)Dichloride on the Viability and the Productions of Tumor Necrosis Factor α and Interleukin-12 in Murine Macrophage Cell Line, J774.1.
dibutyltin macrophages interleukin-10 interleukin-12
2009/3/16
Immunotoxicity is one of toxic effects of dibutyltin(DBT)compounds. In our previous study, the inhibitory effects of DBT on the productions of tumor necrosis a(TNFα)and interleukin-1β in a murine macr...