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观察脑通胶囊对血管性痴呆(VD)大鼠学习记忆、海马N-甲基-D-天冬氨酸(NMDA)受体及锥体细胞的影响。 方法: 随机抽取大鼠19只作为假手术组,其余采用改良的四血管法(4-VO)制备VD模型并随机分为模型组、尼莫地平组(12 mg·kg-1·d-1)、脑通胶囊高剂量组(1 200 mg·kg-1·d-1)、脑通胶囊中剂量组(600 mg·kg-1·d-1)、脑通胶囊低剂量组(300 mg·kg...
Lead exposure impairs NMDA agonist-induced no production in pyramidal hippocampal cells
Lead acetate ACBD NMDA agonist Pyramidal cell Nitric oxide Culture
2010/2/1
Chronic exposure to Lead (Pb) affects neural functions in central nervous system (CNS) particularly the learning and memory. On the other hand, alteration of calcium level in the CNS results in activa...